Engineering 2D Cu-composed metal-organic framework nanosheets for augmented nanocatalytic tumor therapy.

ABSTRACT: The engineered nanoformulation that can be activated by intracellular tumor microenvironment, including acidic pH, overexpressed H₂O₂, and high concentration of glutathione (GSH), features high efficacy to eradicate tumor cells with the intrinsic specificity and therapeutic biosafety. However, the relatively slow reaction rate of traditional Fe²⁺-mediated Fenton reaction induces the low production amount of reactive oxygen species (ROS) and subsequently the limited therapeutic outcome against tumors. Here, we established Cu (II)-based two-dimensional (2D) metal-organic framework (MOF) nanosheets as a distinct chemoreactive nanocatalyst for GSH-triggered and H₂O₂-augmented chemodynamic therapy (CDT), depending on the "AND" logic gate, f

SUBMITTER: Zhuang S 

PROVIDER: S-EPMC8815149 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature