Somatic mutations in collagens are associated with a distinct tumor environment and overall survival in gastric cancer.

ABSTRACT:

Background

Gastric cancer is a heterogeneous disease with poorly understood genetic and microenvironmental factors. Mutations in collagen genes are associated with genetic diseases that compromise tissue integrity, but their role in tumor progression has not been extensively reported. Aberrant collagen expression has been long associated with malignant tumor growth, invasion, chemoresistance, and patient outcomes. We hypothesized that somatic mutations in collagens could functionally alter the tumor extracellular matrix.

Methods

We used publicly available datasets including The Tumor Cancer Genome Atlas (TCGA) to interrogate somatic mutations in collagens in stomach adenocarcinomas. To demonstrate that collagens were significantly mutated above background mutation rates, we

SUBMITTER: Brodsky AS 

PROVIDER: S-EPMC8815231 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature