Generation of functional human thymic cells from induced pluripotent stem cells.

ABSTRACT:

Background

The thymus is a glandular organ that is essential for the formation of the adaptive immune system by educating developing T cells. The thymus is most active during childhood and involutes around the time of adolescence, resulting in a severe reduction or absence of naive T-cell output. The ability to generate a patient-derived human thymus would provide an attractive research platform and enable the development of novel cell therapies.

Objectives

This study sought to systematically evaluate signaling pathways to develop a refined direct differentiation protocol that generates patient-derived thymic epithelial progenitor cells from multiple induced pluripotent stem cells (iPSCs) that can further differentiate into functional patient-derived thymic epithelial cells

SUBMITTER: Ramos SA 

PROVIDER: S-EPMC8815270 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature