Human Leukocyte Antigen Association Study Reveals DRB1*04:02 Effects Additional to DRB1*07:01 in Anti-LGI1 Encephalitis.

ABSTRACT:

Background and objectives

To study human leukocyte antigen (HLA) allele associations in anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis.

Methods

A multiethnic cohort of 269 patients with anti-LGI1 encephalitis and 1,359 controls was included. Four-digit HLA sequencing and genome wide association single-nucleotide polymorphism typing imputation (0.99 concordance) were used for HLA typing. Significance of primary and secondary associations was tested using χ², Fisher exact tests, or logistic regression with the control of population stratification covariates when applicable.

Results

DRB1*07:01 and DQA1*02:01, 2 alleles in strong linkage disequilibrium, were associated with the disease (90% vs 24%, OR = 27.8, p < 10e^-50) across eth

SUBMITTER: Peris Sempere V 

PROVIDER: S-EPMC8815287 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature