Doxorubicin sensitizes breast cancer cells to natural killer cells in connection with increased Fas receptors.

ABSTRACT: Breast cancer (BC) is the most common cancer in women. Although standard treatments are successful in patients with BC diagnosed at an early stage, an alternative treatment is required for patients with advanced‑stage disease who do not respond to these treatments. The concept of using chemotherapy to sensitize cancer cells to become susceptible to immunotherapy was recently introduced and may be used as an alternative treatment for BC. The chemotherapeutic drug doxorubicin has been reported to sensitize cancer cells; however, the efficacy to sensitize the solid spheroids, in addition to its underlying mechanism regarding how doxorubicin sensitizes BC, has not previously been explored. In the present study, the effectiveness of a combined treatment of doxorubicin and natural killer‑92 (NK‑

SUBMITTER: Sawasdee N 

PROVIDER: S-EPMC8815410 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature