Cognitive Function and Uremic Toxins after Kidney Transplantation: An Exploratory Study.

ABSTRACT:

Background

Cognitive functions are altered in patients with CKD. However, it is suggested that cognitive functions improve after kidney transplantation, at least partially. A possible cause for this improvement could be the reduction of uremic retention solutes after transplantation. This study assessed the association between the changes in uremic toxin concentration with the changes in cognitive function in patients after kidney transplantation.

Methods

Ten recipients of kidney transplants were compared with 18 controls (nine patients on hemodialysis, and nine patients with CKD stage 4 or 5 [eGFR <30 ml/min per 1.73 m²] who were not on dialysis). An extensive neuropsychological assessment, covering the five major cognitive domains (i.e., memory, attention

SUBMITTER: Te Linde E 

PROVIDER: S-EPMC8815524 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature