Induction and Donor Specific Antibodies in Low Immunologic Risk Kidney Transplant Recipients.

ABSTRACT:

Background

Optimal induction for patients without pretransplant donor-specific antibodies (DSAs) is poorly defined. The goal of this study was to compare the incidence of de novo DSA (dnDSA) and graft outcomes between induction therapies in patients with a negative virtual crossmatch (VXM).

Methods

A retrospective chart review was performed, identifying 782 patients with a negative VXM who underwent kidney transplantation at a single, high-volume institution between January 2013 and May 2017. Kaplan-Meier analysis was used to assess the incidence of dnDSA and allograft survival between induction therapies in this group. dnDSA is defined as the development of new post-transplant DSA, at any MFI level.

Results

Induction therapy included alemtuzumab (N=87,

SUBMITTER: Bath NM 

PROVIDER: S-EPMC8815535 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature