Association of FGF23 with Incident Sepsis in Community-Dwelling Adults: A Cohort Study.

ABSTRACT:

Background

Fibroblast growth factor 23 (FGF23) is a hormone that regulates vitamin D activity. Higher circulating FGF23 concentrations have been associated with an increased risk of infection-related hospitalization, but the association of FGF23 with risk of sepsis remains unclear.

Methods

We examined the association of FGF23 with incident sepsis events in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a national longitudinal cohort of black and white adults ≥45 years of age. Using a case-cohort design, we measured baseline FGF23 in 703 sepsis cases and in 991 participants randomly selected from the REGARDS cohort. We defined sepsis as the presence of a serious infection plus two or more Systemic Inflammatory Response Syndrome criteria. We ident

SUBMITTER: Paul S 

PROVIDER: S-EPMC8815598 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature