Single Lumen Alternating Micro-Batch Hemodiafiltration (SLAMB-HDF): A Device for Minimally Invasive Renal Replacement Therapy.

ABSTRACT: Blood-based RRT, such as hemodialysis, requires access to the bloodstream and adequate blood flow to enable the requisite clearance. As such, nearly all RRT systems require two lumens, enabling a blood circuit that pulls blood from one lumen or needle and returns it via another lumen or needle. The proposed single lumen alternating micro-batch (SLAMB) technique uses a small single lumen to draw a "micro" batch of blood into a single reservoir. In the reservoir, the "batch" of blood is circulated at a high blood flow rate through a hemofilter or hemodialyzer, enabling efficient small- and middle-molecule clearance. Thereafter, the "purified" blood is returned to the patient and the cycle is repeated. Each batch comprises 20-300 ml of blood, which is adjusted to the vascular access, h

SUBMITTER: Chawla LS 

PROVIDER: S-EPMC8815610 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature