Association between benzodiazepine premedication and 30-day mortality rate: A propensity-score weighted analysis of the Peri-interventional Outcome Study in the Elderly (POSE).

ABSTRACT:

Background

Recent guidelines suggest that benzodiazepine premedication should be avoided in elderly patients, though with limited supporting evidence.

Objective

We conducted a secondary analysis of the POSE data to explore the association of premedication in patients aged 80 years or older with 30-day mortality.

Design

We used propensity score methods to perform a confounder-adjusted time-to-event analysis of the association between benzodiazepine premedication and 30-day mortality of the POSE study.

Setting

POSE was conducted as a European multicentre prospective cohort study.

Patients

Adults aged 80 years or older scheduled for surgical or nonsurgical intervention under anaesthesia.

Results

A total of 9497 patients were analysed. One thousand fi

SUBMITTER: Kowark A 

PROVIDER: S-EPMC8815825 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature