The nuclear receptor Hr46/Hr3 is required in the blood brain barrier of mature males for courtship.

ABSTRACT: The blood brain barrier (BBB) forms a stringent barrier that protects the brain from components in the circulation that could interfere with neuronal function. At the same time, the BBB enables selective transport of critical nutrients and other chemicals to the brain. Beyond these functions, another recently recognized function is even less characterized, specifically the role of the BBB in modulating behavior by affecting neuronal function in a sex-dependent manner. Notably, signaling in the adult Drosophila BBB is required for normal male courtship behavior. Courtship regulation also relies on male-specific molecules in the BBB. Our previous studies have demonstrated that adult feminization of these cells in males significantly lowered courtship. Here, we conducted microarray analysis o

SUBMITTER: Lama C 

PROVIDER: S-EPMC8815886 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature