Association of ischemic stroke onset time with presenting severity, acute progression, and long-term outcome: A cohort study.

ABSTRACT:

Background

Preclinical data suggest circadian variation in ischemic stroke progression, with more active cell death and infarct growth in rodent models with inactive phase (daytime) than active phase (nighttime) stroke onset. We aimed to examine the association of stroke onset time with presenting severity, early neurological deterioration (END), and long-term functional outcome in human ischemic stroke.

Methods and findings

In a Korean nationwide multicenter observational cohort study from May 2011 to July 2020, we assessed circadian effects on initial stroke severity (National Institutes of Health Stroke Scale [NIHSS] score at admission), END, and favorable functional outcome (3-month modified Rankin Scale [mRS] score 0 to 2 versus 3 to 6). We included 17,461 consecutive p

SUBMITTER: Ryu WS 

PROVIDER: S-EPMC8815976 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature