Double-blind randomized N-of-1 trial of transcranial alternating current stimulation for mal de debarquement syndrome.

ABSTRACT:

Background

Mal de Débarquement Syndrome (MdDS) is a medically refractory neurotological disorder characterized by persistent oscillating vertigo that follows a period of entrainment to oscillating motion such as experienced during sea or air travel. Fronto-occipital hypersynchrony may correlate with MdDS symptom severity.

Materials and methods

Individuals with treatment refractory MdDS lasting at least 6 months received single administrations of three fronto-occipital transcranial alternating current stimulation (tACS) protocols in an "n-of-1" double-blind randomized design: alpha frequency anti-phase, alpha-frequency in-phase, and gamma frequency control. Baseline assessments were made on Day 1. The treatment protocol that led to the most acute reduction in symptoms during

SUBMITTER: Cha YH 

PROVIDER: S-EPMC8815977 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature