Nucleation of the Theophylline:Salicylic Acid 1:1 Cocrystal.

ABSTRACT: The nucleation behavior of the theophylline-salicylic acid 1:1 (THP:SA) cocrystal in chloroform has been investigated and compared with the corresponding behavior of the pure compounds. Induction times have been determined at different supersaturations at 10 °C under each condition in approximately 40-80 repetition experiments in 20 mL vials. Nucleation times, extracted from the median induction times by accounting for a nucleus growth time, have been used to determine the interfacial energy and the pre-exponential factor within the classical nucleation theory. Results show that the cocrystal at equal driving force has a longer nucleation time, or to reach equal nucleation time, the cocrystal requires a higher driving force. Pure theophylline is easier to nucleate than pure salicylic acid,

SUBMITTER: McTague H 

PROVIDER: S-EPMC8816349 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature