Physiological TLR4 regulation in human fetal membranes as an explicative mechanism of a pathological preterm case.

ABSTRACT: The integrity of human fetal membranes is crucial for harmonious fetal development throughout pregnancy. Their premature rupture is often the consequence of a physiological phenomenon that has been exacerbated. Beyond all the implied biological processes, inflammation is of primary importance and is qualified as 'sterile' at the end of pregnancy. In this study, complementary methylomic and transcriptomic strategies on amnion and choriodecidua explants obtained from the altered (cervix zone) and intact fetal membranes at term and before labour were used. By cross-analysing genome-wide studies strengthened by in vitro experiments, we deciphered how the expression of toll-like receptor 4 (TLR4), an actor in pathological fetal membrane rupture, is controlled. Indeed, it is differentially regul

SUBMITTER: Belville C 

PROVIDER: S-EPMC8816379 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature