Cystatin C relates to metabolism in healthy, pubertal adolescents.

ABSTRACT:

Introduction

The cystatin C (CysC) serum level is a marker of glomerular filtration rate and depends on age, gender, and pubertal stage. We hypothesize that CysC might overall reflect energy homeostasis and be regulated by components of the endocrine system and metabolites in pubertal adolescents.

Methods

Serum CysC levels and further possible effector parameters in 5355 fasting, morning venous blood samples from 2035 healthy participants of the LIFE Child cohort study (age 8 to 18 years) were analyzed. Recruitment started in 2011, with probands followed up once a year. Linear univariate and stepwise multivariate regression analyses were performed.

Results

Annual growth rate, serum levels of thyroid hormones, parathyroid hormone, insulin-like growth factor 1, hemoglob

SUBMITTER: Ziegelasch N 

PROVIDER: S-EPMC8816513 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature