Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy.

ABSTRACT: Despite the extensive and rapid discovery of modern drugs for treatment of cancer, microbial infections, and viral illnesses; these diseases are still among major global health concerns. To take inspiration from natural nucleases and also the therapeutic potential of metallopeptide antibiotics such as the bleomycin family, artificial metallonucleases with the ability of promoting DNA/RNA cleavage and eventually affecting cellular biological processes can be introduced as a new class of therapeutic candidates. Metal complexes can be considered as one of the main categories of artificial metalloscissors, which can prompt nucleic acid strand scission. Accordingly, biologists, inorganic chemists, and medicinal inorganic chemists worldwide have been designing, synthesizing and evaluating the bi

SUBMITTER: Anjomshoa M 

PROVIDER: S-EPMC8816526 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature