Comparison of Biochemical Parameters between Mouse Model and Human after Paraquat Poisoning.

ABSTRACT:

Background

This study was designed to investigate differences in biochemical parameters between mouse and humans after paraquat (PQ) poisoning and develop a suitable animal model for studying organ damage after PQ poisoning. The prognostic factors of PQ-poisoned patients were further analyzed.

Methods

Thirty C57BL/6J mice were randomly divided into five groups (control, sham, and 3 PQ doses), and the mouse model was established by intragastric administration of PQ. Physiological indexes such as the body weight, mental state, and mortality rate were observed. Biochemical parameters were analyzed 24 h after PQ poisoning. We also performed a retrospective analysis of clinical data from 29 patients with PQ poisoning admitted to the Emergency Department of the Affiliated Hospital

SUBMITTER: Yu J 

PROVIDER: S-EPMC8816545 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature