Post translational modifications of Trifolitoxin: a blue fluorescent peptide antibiotic.

ABSTRACT: Trifolitoxin (TFX, C₄₁H₆₃N₁₅O₁₅S) is a selective, ribosomally-synthesized, post-translationally modified, peptide antibiotic, produced by Rhizobium leguminosarum bv. trifolii T24. TFX specifically inhibits α-proteobacteria, including the plant symbiont Rhizobium spp., the plant pathogen Agrobacterium spp. and the animal pathogen Brucella abortus. TFX-producing strains prevent legume root nodulation by TFX-sensitive rhizobia. TFX has been isolated as a pair of geometric isomers, TFX1 and TFX2, which are derived from the biologically inactive primary amino acid sequence: Asp-Ile-Gly-Gly-Ser-Arg-Gln-Gly-Cys-Val-Ala. Gly-Cys is present as a thiazoline ring and the Arg-Gln-Gly sequence is extensively modified to a UV absorbing, blue fluorescent chromo

SUBMITTER: Lethbridge BJ 

PROVIDER: S-EPMC8816728 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature