SMAD4 mutations do not preclude epithelial-mesenchymal transition in colorectal cancer.

ABSTRACT: Transforming growth factor beta (TGFβ) superfamily signaling is a prime inducer of epithelial-mesenchymal transitions (EMT) that foster cancer cell invasion and metastasis, a major cause of cancer-related deaths. Yet, TGFβ signaling is frequently inactivated in human tumor entities including colorectal cancer (CRC) and pancreatic adenocarcinoma (PAAD) with a high proportion of mutations incapacitating SMAD4, which codes for a transcription factor (TF) central to canonical TGFβ and bone morphogenetic protein (BMP) signaling. Beyond its role in initiating EMT, SMAD4 was reported to crucially contribute to subsequent gene regulatory events during EMT execution. It is therefore widely assumed that SMAD4-mutant (SMAD4^mut) cancer cells are unable to undergo EMT. Here, we scrutinized t

SUBMITTER: Frey P 

PROVIDER: S-EPMC8816731 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature