Elevated baseline C-reactive protein levels predict poor progression-free survival in sporadic vestibular schwannoma.

ABSTRACT:

Background

Recent investigations showed emerging evidence of the role of inflammation in the growth of sporadic vestibular schwannoma (VS). The present retrospective study investigated the impact of systemic inflammation on tumor progression using serum C-reactive protein (CRP) levels in a series of 87 surgically treated sporadic VS patients.

Methods

The optimal cut-off value for CRP was defined as 3.14 mg/dl according to the receiver operating characteristic curve (AUC: 0.70, 95% CI 0.47-0.92). Patient cohort was dichotomized into normal (n = 66; < 3.14 mg/dl) and high baseline (n = 21; ≥ 3.14 mg/dl) CRP groups.

Results

No significant differences in age, sex, comorbidities influencing the systemic inflammatory state, Karnofsky performance status (KPS), tumor size, ex

SUBMITTER: Wach J 

PROVIDER: S-EPMC8816751 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature