Stoney vs. Histed: Quantifying the spatial effects of intracortical microstimulation.

ABSTRACT:

Background

Intracortical microstimulation (ICMS) is used to map neural circuits and restore lost sensory modalities such as vision, hearing, and somatosensation. The spatial effects of ICMS remain controversial: Stoney and colleagues proposed that the volume of somatic activation increased with stimulation intensity, while Histed et al., suggested activation density, but not somatic activation volume, increases with stimulation intensity.

Objective

We used computational modeling to quantify the spatial effects of ICMS intensity and unify the apparently paradoxical findings of Histed and Stoney.

Methods

We implemented a biophysically-based computational model of a cortical column comprising neurons with realistic morphology and representative synapses. We quantified th

SUBMITTER: Kumaravelu K 

PROVIDER: S-EPMC8816873 | biostudies-literature | 2022 Jan-Feb

REPOSITORIES: biostudies-literature