The influence of CD26⁺ and CD26^- fibroblasts on the regeneration of human dermo-epidermal skin substitutes.

ABSTRACT: CD26, also known as dipeptidyl peptidase IV (DPPIV), is a multifunctional transmembrane protein playing a significant role in the cutaneous wound healing processes in the mouse skin. However, only scarce data are available regarding the distribution and function of this protein in the human skin. Therefore, the aim of this study was to investigate the impact of CD26 deficiency in human primary fibroblasts on the regeneration of human tissue-engineered skin substitutes in vivo. Dermo-epidermal skin analogs, based on collagen type I hydrogels, were populated either with human CD26⁺ or CD26^knockout fibroblasts and seeded with human epidermal keratinocytes. These skin substitutes were transplanted onto the back of immune-incompetent rodents. Three weeks post-transplantati

SUBMITTER: Michalak-Micka K 

PROVIDER: S-EPMC8816920 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature