The relationship between simulated milrinone exposure and hypotension in children.

ABSTRACT:

Introduction

Hypotension is an adverse event that may be related to systemic exposure of milrinone; however, the true exposure-safety relationship is unknown.

Methods

Using the Pediatric Trials Network multicentre repository, we identified children ≤17 years treated with milrinone. Hypotension was defined according to age, using the Pediatric Advanced Life Support guidelines. Clinically significant hypotension was defined as hypotension with concomitant lactate >3 mg/dl. A prior population pharmacokinetic model was used to simulate milrinone exposures to evaluate exposure-safety relationships.

Results

We included 399 children with a median (quarter 1, quarter 3) age of 1 year (0,5) who received 428 intravenous doses of milrinone (median infusion rate 0.31 mcg/kg/min [

SUBMITTER: Commander SJ 

PROVIDER: S-EPMC8816969 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature