Gold Nanoclusters as Nanoantibiotic Auranofin Analogues.

ABSTRACT: Auranofin, a gold(I)-complex with tetraacetylated thioglucose (Ac₄ GlcSH) and triethylphosphine ligands, is an FDA-approved drug used as an anti-inflammatory aid in the treatment of rheumatoid arthritis. In repurposing auranofin for other diseases, it was found that the drug showed significant activity against Gram-positive but was inactive against Gram-negative bacteria. Herein, the design and synthesis of gold nanoclusters (AuNCs) based on the structural motif of auranofin are reported. Phosphine-capped AuNCs are synthesized and glycosylated, yielding auranofin analogues with mixed triphenylphosphine monosulfonate (TPPMS)/Ac₄ GlcSH ligand shells. These AuNCs are active against both Gram-negative and Gram-positive bacteria, including multidrug-resistant pathogens. No

SUBMITTER: Ndugire W 

PROVIDER: S-EPMC8816973 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature