Ontology highlight
ABSTRACT:
SUBMITTER: Zhi Z
PROVIDER: S-EPMC8817011 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Zhi Zhe Z Ouyang Zhenlin Z Ren Yibo Y Cheng Ying Y Liu Peijun P Wen Yurong Y Shao Yongping Y
Cell death and differentiation 20210830 2
Bmf contributes to the onset of anoikis by translocating from cytoskeleton to mitochondria when cells lose attachment to the extracellular matrix. However, the structural details of Bmf cytoskeleton tethering and the control of Bmf release upon loss of anchorage remained unknown. Here we showed that cell detachment induced rapid and sustained activation of p38 MAPK in mammary epithelial cell lines. Inhibition of p38 signaling or Bmf knockdown rescued anoikis. Activated p38 MAPK could directly ph ...[more]