Association Between Benzodiazepine and Opioid Prescription and Mortality Among Patients in a Large Healthcare System.

ABSTRACT:

Objective

Coprescription of opioids and benzodiazepines (BDZ) is associated with adverse outcomes, including greater healthcare utilization and overdose risk. This study aims to examine opioid and BDZ coprescription, dosing, and mortality among patients with and without opioid use disorder (OUD) in a large healthcare system.

Methods

Using data from the California state Prescription Drug Monitoring Program during 2010 to 2014 linked with a large healthcare system electronic health record database and mortality records from the Centers for Disease Control National Death Index, this study examined 5202 patients (1978 with OUD, 3224 controls). Multiple logistic regression analyses were conducted to examine relationships between most recent BDZ and opioid prescription, and their

SUBMITTER: Mooney LJ 

PROVIDER: S-EPMC8817063 | biostudies-literature | 2022 Jan-Feb 01

REPOSITORIES: biostudies-literature