MiR-155-regulated mTOR and Toll-like receptor 5 in gastric diffuse large B-cell lymphoma.

ABSTRACT:

Background

Gastric diffuse large B-cell lymphoma (DLBCL) is often associated with Helicobacter pylori (H. pylori) infection. Those in the early stage could be treated with H. pylori eradication therapy, and are classified into a sensitive group and a resistant group.

Methods

Genome-wide miRNA and miRNA expression profiles were obtained from biopsy specimens of gastric DLBCL. MiRNAs and their targets as predictors of responses to H. pylori eradication therapy were identified through differential expression and pathway enrichment analysis, and further confirmed with transfection experiments in lymphoma cell lines of B-cell origin.

Results

Genome-wide miRNA and mRNA profiles showed miR-200 was associated with the sensitive group, and that the resistant group had higher l

SUBMITTER: Huang WT 

PROVIDER: S-EPMC8817081 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature