Aspartate aminotransferase/alanine aminotransferase ratio and subsequent cancer development.

ABSTRACT:

Background

We aimed to evaluate the association between the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio and subsequent development of any type of cancer in an apparently healthy population.

Methods

We conducted a retrospective cohort study at St. Luke's International Hospital, Tokyo, Japan between 2005 and 2018. All participants who visited for voluntary health checkups were included. We divided the participants into different quintiles based on the baseline AST/ALT ratios and examined the outcomes.

Results

A total of 85,658 participants were included. The mean age was 44.7 years (standard deviation 12.0) at baseline, and 42,913 (50.1%) of them were men. During a median follow-up of 61.6 months, 4701 (5.5%) participants developed some type of

SUBMITTER: Kobayashi D 

PROVIDER: S-EPMC8817090 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature