Uridine alleviates carbon tetrachloride-induced liver fibrosis by regulating the activity of liver-related cells.

ABSTRACT: At present, liver fibrosis is a major challenge of global health. When hepatocyte regeneration cannot compensate for hepatocyte death, it will develop into liver fibrosis in chronic liver disease. Initially, collagen produced by myofibroblasts plays a role in maintaining liver integrity, but excessive collagen accumulation can inhibit the residual liver function, leading to liver failure. At present, many scientists are actively looking for drugs to alleviate liver fibrosis. In the current study, we investigated the potential role of uridine in the treatment of liver fibrosis (uridine is a plant/animal-derived pyrimidine nucleoside, therefore uridine can also be ingested and absorbed by the body, accompanied by the process of food intake). For this, we systematically studied the effect of

SUBMITTER: Zheng WV 

PROVIDER: S-EPMC8817115 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature