FGF21 alleviates acute liver injury by inducing the SIRT1-autophagy signalling pathway.

ABSTRACT: Liver injury can lead to different hepatic diseases, which are the mainly causes of high global mortality and morbidity. Autophagy and Sirtuin type 1 (SIRT1) have been shown protective effects in response to liver injury. Previous studies have showed that Fibroblast growth factor 21 (FGF21) could alleviate acute liver injury (ALI), but the mechanism remains unclear. Here, we verified the relationship among FGF21, autophagy and SIRT1 in carbon tetrachloride (CCl₄ )-induced ALI. We established CCl₄ -induced ALI models in C57BL/6 mice and the L02 cell line. The results showed that FGF21 was robustly induced in response to stress during the development of ALI. After exogenous FGF21 treatment in ALI models, liver damage in ALI mice was significantly reduced, as well as ser

SUBMITTER: Yang X 

PROVIDER: S-EPMC8817117 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature