Biological and molecular profile of fracture non-union tissue: A systematic review and an update on current insights.

ABSTRACT: Fracture non-union represents a common complication, seen in 5%-10% of all acute fractures. Despite the enhancement in scientific understanding and treatment methods, rates of fracture non-union remain largely unchanged over the years. This systematic review investigates the biological, molecular and genetic profiles of both (i) non-union tissue and (ii) non-union-related tissues, and the genetic predisposition to fracture non-union. This is crucially important as it could facilitate earlier identification and targeted treatment of high-risk patients, along with improving our understanding on pathophysiology of fracture non-union. Since this is an update on our previous systematic review, we searched the literature indexed in PubMed Medline; Ovid Medline; Embase; Scopus; Google Scholar; an

SUBMITTER: Panteli M 

PROVIDER: S-EPMC8817135 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature