A novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold with enhanced osteoporotic osseointegration through osteoimmunomodulation.

ABSTRACT:

Background

Femoral stem of titanium alloy has been widely used for hip arthroplasty with considerable efficacy; however, the application of this implant in patients with osteoporosis is limited due to excessive bone resorption. Macrophages participate in the regulation of inflammatory response and have been a topic of increasing research interest in implant field. However, few study has explored the link between macrophage polarization and osteogenic-osteoclastic differentiation. The present study aims to develop a novel hierarchical biofunctionalized 3D-printed porous Ti6Al4V scaffold with enhanced osteoporotic osseointegration through immunotherapy.

Method

To improve the osteointegration under osteoporosis, we developed a hierarchical biofunctionalized 3D-printed porous Ti

SUBMITTER: Wang W 

PROVIDER: S-EPMC8817481 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature