Measuring axial length of the eye from magnetic resonance brain imaging.

ABSTRACT:

Background

Metrics derived from the human eye are increasingly used as biomarkers and endpoints in studies of cardiovascular, cerebrovascular and neurological disease. In this context, it is important to account for potential confounding that can arise from differences in ocular dimensions between individuals, for example, differences in globe size.

Methods

We measured axial length, a geometric parameter describing eye size from T₂-weighted brain MRI scans using three different image analysis software packages (Mango, ITK and Carestream) and compared results to biometry measurements from a specialized ophthalmic instrument (IOLMaster 500) as the reference standard.

Results

Ninety-three healthy research participants of mean age 51.0 ± SD 5.4 years were analy

SUBMITTER: Wiseman SJ 

PROVIDER: S-EPMC8817515 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature