CCR2-overexpressing mesenchymal stem cells targeting damaged liver enhance recovery of acute liver failure.

ABSTRACT:

Background

Mesenchymal stem cell (MSC) transplantation is emerging as a promising cell therapeutic strategy in acute liver failure (ALF) clinical research. The potency of MSCs to migrate and engraft into targeted lesions could largely determine their clinical efficacy, in which chemokine/receptor axes play a crucial role. Unfortunately, the downregulation of chemokine receptors expression after in vitro expansion results in a poor homing capacity of MSCs.

Methods

By evaluating the chemokine expression profile in the liver of ALF patients and ALF mice, we found that CCL2 expression was highly upregulated in damaged livers, while the corresponding receptor, CCR2, was lacking in cultured MSCs. Thus, we genetically modified MSCs to overexpress CCR2 and investigated the targeted

SUBMITTER: Xu R 

PROVIDER: S-EPMC8817567 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature