The effect of first- and third-generation prophylactic antibiotics on hospitalization and medical expenditures for cardiac surgery.

ABSTRACT:

Background

This study investigated the efficacy of first-generation (cefazolin) and third-generation (ceftizoxime) prophylactic antibiotics in patients undergoing cardiac surgery and the incidence of surgical site infections, hospitalizations, and medical costs.

Methods

All adult patients (≥ 20 years) undergoing cardiac surgery at one hospital from January 01, 2009, to December 31, 2016, were included in this study. A single prophylactic antibiotic was administered at a dose of 1 g within one hour of the surgical incision and for three days after surgery at eight-hour intervals. After propensity score matching, 194 patients in each antibiotic prophylaxis group (first-generation vs third-generation) were analyzed. Among the 388 patients, the incidence of surgical site infecti

SUBMITTER: Bae SJ 

PROVIDER: S-EPMC8817574 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature