Survival impact of prophylactic cranial irradiation in small-cell lung cancer in the modern era of magnetic resonance imaging staging.

ABSTRACT:

Background

In the modern era of magnetic resonance imaging (MRI) staging, the benefit of prophylactic cranial irradiation (PCI) in patients with small-cell lung cancer (SCLC) has been controversial. This study evaluated the prognostic impact of PCI in patients with limited- or extensive-stage SCLC who had no brain metastases at diagnosis according to MRI.

Methods

Data from newly diagnosed patients in 2014 from the Korean Association for Lung Cancer Registry database were used. Patients with limited- or extensive-stage SCLC who had no brain metastases according to MRI were identified. Univariate and multivariate survival analyses were conducted to assess the prognostic association of PCI.

Results

Of 107 and 122 patients with limited- and extensive-stage SCLC, 24% and 1

SUBMITTER: Lim YJ 

PROVIDER: S-EPMC8817587 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature