Neuroradiological differentiation of white matter lesions in patients with multiple sclerosis and Fabry disease.

ABSTRACT:

Objective

White matter lesions (WML) in multiple sclerosis (MS) differ from vascular WML caused by Fabry disease (FD). However, in atypical cases the discrimination can be difficult and may vary between individual raters. The aim of this study was to evaluate interrater reliability of WML differentiation between MS and FD patients.

Materials and methods

Brain MRI scans of 21 patients with genetically confirmed FD were compared to 21 matched patients with MS. Pseudonymized axial FLAIR sequences were assessed by 6 blinded raters and attributed to either the MS or the FD group to investigate interrater reliability. Additionally, localization of WML was compared between the two groups.

Results

The median age of patients was 46 years (IQR 35-58). Interrater reliability was

SUBMITTER: Rath J 

PROVIDER: S-EPMC8817613 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature