Genomic insights into virulence factors affecting tissue-invasive Klebsiella pneumoniae infection.

ABSTRACT:

Background

The key virulence factors responsible for hypervirulent Klebsiella pneumoniae (hvKp) infection remains elusive.

Methods

We analyzed K. pneumoniae isolates collected between 2017 and 2019 and defined hvKp as a pyogenic infection. Classical K. pneumoniae (cKp) involved a non-invasive infection or uncomplicated bacteremia. Isolates belonging to the K. pneumoniae species complex were excluded.

Results

We analyzed 112 isolates, including 19 hvKp, 67 cKp, and 26 colonizers, using whole-genome sequencing. Population genomics revealed that the K1-sequence type (ST) 82 (O1v1) clade was distinct from that of the K1-ST23 (O1v2) clone. The virulence gene profiles also differed between K1-ST82 (aerobactin and rmpA) and K1-ST23 (aerobactin, yersiniabactin, salmochelin, c

SUBMITTER: Matono T 

PROVIDER: S-EPMC8817621 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature