Dataset Information

Meaningful endings and mixed emotions: The double-edged sword of reminiscence on good times.

ABSTRACT: Meaningful endings lead people to experience mixed emotions, but it is unclear why. We hypothesized that it is in part because meaningful endings lead people to reminisce on good times. In Study 1, college students who took part in our study on their graduation day (vs. a typical day) reported having spent more time that day reminiscing on good times. Moreover, reminiscence on good times partially mediated the effect of graduation on happiness, sadness, and mixed emotions. In Study 2, we asked undergraduates to reminisce on good (vs. ordinary) times from high school and found that reminiscence on good times elicited happiness, sadness, and mixed emotions. In Study 3, we found that reminiscing on good times that were not (vs. were) repeatable elicited especially intense sadness and mixed emotions. Taken together, results indicate that reminiscing on good times, especially good times gone, elicits mixed emotions and that these emotional consequences help explain why meaningful endings elicit mixed emotions. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

SUBMITTER: Larsen JT

PROVIDER: S-EPMC8817627 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Meaningful endings and mixed emotions: The double-edged sword of reminiscence on good times.

Larsen Jeff T JT Hershfield Hal E HE Cazares James L JL Hogan Candice L CL Carstensen Laura L LL

Emotion (Washington, D.C.) 20210930 8

Meaningful endings lead people to experience mixed emotions, but it is unclear why. We hypothesized that it is in part because meaningful endings lead people to reminisce on good times. In Study 1, college students who took part in our study on their graduation day (vs. a typical day) reported having spent more time that day reminiscing on good times. Moreover, reminiscence on good times partially mediated the effect of graduation on happiness, sadness, and mixed emotions. In Study 2, we asked u ...[more]

PMID: 34591508

Similar Datasets

Project description:Prion diseases are infectious protein misfolding disorders of the central nervous system that result from misfolding of the cellular prion protein (PrPC) into the pathologic isoform PrPSc. Pathologic hallmarks of prion disease are depositions of pathological prion protein PrPSc, neuronal loss, spongiform degeneration and astrogliosis in the brain. Prion diseases affect human and animals, there is no effective therapy, and they invariably remain fatal. For a long time, neuronal loss was considered the sole reason for neurodegeneration in prion pathogenesis, and the contribution of non-neuronal cells like microglia and astrocytes was considered less important. Recent evidence suggests that neurodegeneration during prion pathogenesis is a consequence of a complex interplay between neuronal and non-neuronal cells in the brain, but the exact role of these non-neuronal cells during prion pathology is still elusive. Astrocytes are non-neuronal cells that regulate brain homeostasis under physiological conditions. However, astrocytes can deposit PrPSc aggregates and propagate prions in prion-infected brains. Additionally, sub-populations of reactive astrocytes that include neurotrophic and neurotoxic species have been identified, differentially expressed in the brain during prion infection. Revealing the exact role of astrocytes in prion disease is hampered by the lack of in vitro models of prion-infected astrocytes. Recently, we established a murine astrocyte cell line persistently infected with mouse-adapted prions, and showed how such astrocytes differentially process various prion strains. Considering the complexity of the role of astrocytes in prion pathogenesis, we need more in vitro and in vivo models for exploring the contribution of sub-populations of reactive astrocytes, their differential regulation of signaling cascades, and the interaction with neurons and microglia during prion pathogenesis. This will help to establish novel in vivo models and define new therapeutic targets against prion diseases. In this review, we will discuss the complex role of astrocytes in prion disease, the existing experimental resources, the challenges to analyze the contribution of astrocytes in prion disease pathogenesis, and future strategies to improve the understanding of their role in prion disease.

Dataset Information

Meaningful endings and mixed emotions: The double-edged sword of reminiscence on good times.

Publications

Meaningful endings and mixed emotions: The double-edged sword of reminiscence on good times.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets