Reinfection by the SARS-CoV-2 Gamma variant in blood donors in Manaus, Brazil.

ABSTRACT:

Background

The city of Manaus, north Brazil, was stricken by a second epidemic wave of SARS-CoV-2 despite high seroprevalence estimates, coinciding with the emergence of the Gamma (P.1) variant. Reinfections were postulated as a partial explanation for the second surge. However, accurate calculation of reinfection rates is difficult when stringent criteria as two time-separated RT-PCR tests and/or genome sequencing are required. To estimate the proportion of reinfections caused by Gamma during the second wave in Manaus and the protection conferred by previous infection, we identified anti-SARS-CoV-2 antibody boosting in repeat blood donors as a mean to infer reinfection.

Methods

We tested serial blood samples from unvaccinated repeat blood donors in Manaus for the presence o

SUBMITTER: Prete CA 

PROVIDER: S-EPMC8817641 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature