Targeting Toll-Like Receptors in Sepsis: From Bench to Clinical Trials.

ABSTRACT: Significance: Sepsis is a critical clinical syndrome with life-threatening organ dysfunction induced by a dysregulated host response to infection. Despite decades of intensive research, sepsis remains a leading cause of in-hospital mortality with few specific treatments. Recent Advances: Toll-like receptors (TLRs) are a part of the innate immune system and play an important role in host defense against invading pathogens such as bacteria, virus, and fungi. Using a combination of genetically modified animal models and pharmacological agents, numerous preclinical studies during the past two decades have demonstrated that dysregulated TLR signaling may contribute to sepsis pathogenesis. However, many clinical trials targeting inflammation and innate immunity such a

SUBMITTER: Chen F 

PROVIDER: S-EPMC8817700 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature