SMAD4 mutations identified in Iranian patients with colorectal cancer and polyp.

ABSTRACT:

Aim

Search for SMAD4 mutations in Colorectal cancer (CRC) or polyp in Iran.

Background

Colorectal cancer is one of the five prevalent cancers among the Iranian population; however, its molecular mechanisms are not fully understood. The vast majority of CRCs arise from neoplastic polyp.

Methods

Colorectal cancer and polyp lesions with matched normal tissues from patients who had undergone colonoscopy in Taleghani Hospital (January 2009 - November 2010) were included in the study. DNA extraction and PCR-sequencing for exons 5-11 of the SMAD-4 gene were carried out on 39 and 30 specimens of polyp and adenocarcinoma, respectively.

Results

Of cancer and polyp specimens, 33.3% and 28.2%, respectively, were mutated in the Smad-4 gene. The majority of SMAD4 mutations,

SUBMITTER: Najjar Sadeghi R 

PROVIDER: S-EPMC8817749 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature