Association between Circulating Antioxidants and Longevity: Insight from Mendelian Randomization Study.

ABSTRACT:

Background

Antioxidants attracted long-standing attention as promising preventive agents worldwide. Previous observational studies have reported that circulating antioxidants are associated with reduced mortality; however, randomized clinical trials indicate neutral or harmful impacts. The association of long-term circulating antioxidant exposure with longevity is still unclear.

Objectives

We aim to determine whether long-term circulating antioxidant exposure is causally associated with longevity in the general population using the two-sample Mendelian randomization (MR) design.

Methods

Genetic instruments for circulating antioxidants (ascorbate, lycopene, selenium, beta-carotene, and retinol) and antioxidant metabolites (ascorbate, alpha-tocopherol, gamma-tocopherol,

SUBMITTER: Yu Z 

PROVIDER: S-EPMC8817834 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature