A Novel Glutamine Metabolism-Related Gene Signature in Prognostic Prediction of Osteosarcoma.

ABSTRACT:

Purpose

Metabolic reprogramming, as one of the hallmarks of cancer, shows promising translational potential for cancer diagnosis, treatment and prognostic prediction. This study aims to construct and validate a prognostic prediction model for osteosarcoma based on glutamine metabolism-related genes.

Materials and methods

A group of glutamine metabolism-related genes was identified from a public database and intersected with a list of osteosarcoma survival-related genes, and a risk score model based on sixteen glutamine metabolism-related genes was developed by using LASSO penalized Cox regression analysis.

Results

The prognosis of patients in the high-risk group was significantly worse than that of patients in the low-risk group in the training dataset (high- vs low-r

SUBMITTER: Wan L 

PROVIDER: S-EPMC8817953 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature