A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level.

ABSTRACT: The majority of seizures recorded in humans and experimental animal models can be described by a generic phenomenological mathematical model, the Epileptor. In this model, seizure-like events (SLEs) are driven by a slow variable and occur via saddle node (SN) and homoclinic bifurcations at seizure onset and offset, respectively. Here we investigated SLEs at the single cell level using a biophysically relevant neuron model including a slow/fast system of four equations. The two equations for the slow subsystem describe ion concentration variations and the two equations of the fast subsystem delineate the electrophysiological activities of the neuron. Using extracellular K⁺ as a slow variable, we report that SLEs with SN/homoclinic bifurcations can readily occur at the single cell

SUBMITTER: Depannemaecker D 

PROVIDER: S-EPMC8818009 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature