A novel semiautomated method for background activity and biological tumour volume definition to improve standardisation of ¹⁸F-FET PET imaging in glioblastoma.

ABSTRACT:

Background

Multicentre clinical trials evaluating the role of ¹⁸F-Fluoroethyl-L-tyrosine (¹⁸F-FET) PET as a diagnostic biomarker in glioma management have highlighted a need for standardised methods of data analysis. ¹⁸F-FET uptake normalised against background in the contralateral brain is a standard imaging technique to delineate the biological tumour volume (BTV). Quantitative analysis of ¹⁸F-FET PET images requires a consistent and robust background activity. Currently, defining background activity involves the manual selection of an arbitrary region of interest, a process that is subject to large variability. This study aims to eliminate methodological errors in background activity definition through the introduction of a semiautomat

SUBMITTER: Brighi C 

PROVIDER: S-EPMC8818070 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature