Altered central and blood glutathione in Alzheimer's disease and mild cognitive impairment: a meta-analysis.

ABSTRACT:

Background

Increasing evidence implicates oxidative stress (OS) in Alzheimer disease (AD) and mild cognitive impairment (MCI). Depletion of the brain antioxidant glutathione (GSH) may be important in OS-mediated neurodegeneration, though studies of post-mortem brain GSH changes in AD have been inconclusive. Recent in vivo measurements of the brain and blood GSH may shed light on GSH changes earlier in the disease.

Aim

To quantitatively review in vivo GSH in AD and MCI compared to healthy controls (HC) using meta-analyses.

Method

Studies with in vivo brain or blood GSH levels in MCI or AD with a HC group were identified using MEDLINE, PsychInfo, and Embase (1947-June 2020). Standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated for outcom

SUBMITTER: Chen JJ 

PROVIDER: S-EPMC8818133 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature