The pyroptosis-related gene signature predicts prognosis and indicates immune activity in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) remains one of the most common malignant tumors with poor survival. Pyroptosis is a kind of programmed cell death that can regulate the proliferation, invasion, and metastasis of tumor cells. However, the expression levels of pyroptosis-related genes (PRGs) in HCC and their relationship with prognosis are still unclear.

Methods

Our study identified 35 PRGs through bioinformatics analysis that were differentially expressed between tumor samples and nontumor samples. According to these differentially expressed genes, HCC patients could be divided into two groups, cluster 1 and cluster 2. The least absolute shrinkage and selection operator (LASSO) Cox regression method was performed to construct a 10-gene signature that classified HCC p

SUBMITTER: Deng M 

PROVIDER: S-EPMC8818170 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature