Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice.

ABSTRACT:

Background

Maternal obesity impairs embryonic developmental potential and significantly increases the risks of metabolic disorders in offspring. However, the epigenetic transmission mechanism of maternal metabolic abnormalities is still poorly understood.

Methods

We established an obesity model in female mice by high-fat diet (HFD) feeding. The effects of the HFD on the developmental potential of oocytes and embryos, the metabolic phenotype, and epigenetic modifications were investigated. The efficacy of metformin administration was assessed. Finally, the regulatory pathway of epigenetic remodeling during zygotic genome activation (ZGA) was explored.

Results

Maternal HFD consumption significantly impaired glucose tolerance and increased the risk of metabolic disorders

SUBMITTER: Huang J 

PROVIDER: S-EPMC8818203 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature